Covenant on Health and Safety at Work (Arboconvenant). Hbo. Wo. Basisonderwijs. Mavo. Vbo. Havo/vwo. Mbo. Hbo. Wo. 22². Ebook Natuurkunde lezen? Natuurkunde koop je eenvoudig online bij ✓ Vele aanbiedingen bij ✓ Gratis retourneren ✓ 30 dagen bedenktijd. Tweedehands Natuurkunde lezen? Natuurkunde koop je eenvoudig online bij ✓ Vele aanbiedingen bij ✓ Gratis retourneren ✓ 30 dagen.
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Voor het nabootsen van de opbouw van een veestapel is bij het PR het melkveemodel ontwikkeld. Met dit model is het mogelijk om een veestapel samen te stellen waarbij rekening wordt gehouden met verschillen in leeftijd en kalfdatum en met uitstoot van dieren tijdens de lactatie.
Het model geeft aan. Her portraits, landscapes and still life paintings are full of life and shining colours. Charged of emotional empathy they catch the attention of the viewer and are reminding us that life is beautiful and worth living in spite of all difficulties we have to go through. Contemporary Dutch painter Hanne Blitz captures visitors’ responses to art and architecture, sweeping vistas and symbolic memorials.
The exhibition is composed by eleven wood artworks with the expression of movement as theme. The artworks are the result of harmonics math applied to sculpture.
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The powerful black colour is dominated by the light source, generating reflexes and modulations. The result is a continuous variation of perspective visions. The works generate, at a first approach, an emotion of mystery and incomprehension, only a deeper contemplation lets one discover entangling and mutative details, evidencing the elegance of the lines and letting the meaning emerge.
Mice lacking Brinp2 or Brinp3, or both, exhibit behaviours consistent with neurodevelopmental disorders. Directory of Open Access Journals Sweden. Full Text Available Background: Genomic validation was carried out for each knock-out line, followed by histological, weight and behavioural examination. Brinp3 is important in moderation of anxiety, with potential relevance to anxiety disorders.
Brinp2 dysfunction resulting in hyperactivity may be relevant to the association of ADHD with chromosome locus 1q Dopamine D3 receptor knockout mice exhibit abnormal nociception in a sex-different manner. Pain is a complex and subjective experience. Previous studies have shown that mice lacking the dopamine D3 receptor D3RKO exhibit hypoalgesia, indicating a role of the D3 receptor in modulation of nociception.
Given that there are sex differences in pain perception, there may be differences in responses to nociceptive stimuli between male and female D3RKO mice. In the current study, we examined the role of the D3 receptor in modulating nociception in male and female D3RKO mice. Acute thermal pain was modeled by hot-plate test.
The von Frey hair test was applied to evaluate mechanical pain. And persistent pain produced by peripheral tissue injury and inflammation was modeled by formalin test. In the hot-plate test, compared with wild-type WT miceD3RKO mice generally exhibited longer latencies at each of the three temperatures. In the formalin test, the male D3RKO mice displayed a similar nociceptive behavior as their sex-matched WT littermates, whereas significantly depressed late-phase formalin-induced nociceptive behaviors were observed in the female mutants.
These findings indicated that the D3 receptor affects nociceptive behaviors in a sex-specific manner and that its absence induces more analgesic behavior in the female knockout mice. An ethanolic extract of Desmodium adscendens exhibits antipsychotic-like activity in mice.
Desmodium adscendens extract DAE is used traditionally in Ghana for the management of psychosis. The present study aimed at providing pharmacological evidence for its ethnomedical use by testing the hypothesis that an ethanolic extract of Desmodium adscendens may possess antipsychotic properties. The primary behavioral effects of DAE on the central nervous system of mice were investigated using Irwin’s test paradigm.
Novelty-induced and apomorphine-induced locomotor and rearing behaviors in mice were explored in an open-field observational test system. Apomorphine-induced cage climbing test in mice was used as the antipsychotic animal model. The ability of DAE to induce catalepsy and enhance haloperidol-induced catalepsy was also investigated in mice. The DAE produced sedation, cholinergic- and serotonergic-like effects in mice when evaluated using the Irwin’s test.
No lethality was observed after 24 h post-treatment. The DAE significantly decreased the frequency of novelty- and apomorphine-induced rearing and locomotor activities in mice. It also significantly lowered the frequency and duration of apomorphine-induced climbing activities in mice.
The ethanolic extract of Desmodium adscendens exhibited antipsychotic-like activities in mice. Motor side effects are only likely to develop at higher doses of the extract. Obese mice exhibit an altered behavioural and inflammatory response to lipopolysaccharide. Obesity is associated with an increase in the prevalence and severity of infections. An altered inflammatory response to LPS was also observed in obese mice compared with controls: These findings could help explain why obese humans show increased sensitivity to infections.
Social behavior is often described as a unified concept, but highly social group-living species exhibit distinct social structures and may make different social decisions. Prairie voles Microtus ochrogaster are socially monogamous rodents that often reside in extended family groups, and exhibit robust preferences for familiar social partners same- and opposite-sex during extended choice tests, although short-term preferences are not known.
Mice Mus musculus are gregarious and colonial, but in brief laboratory tests of social preference they typically prefer social novelty.
This preference for novel vs. However, the tests used to measure preferences in each species differ markedly in duration and degree of contact, such that the behaviors cannot be directly compared. We assessed whether social preferences for novelty or familiarity differed between mice and prairie voles of both sexes when assessed with matching protocols: A subset of voles also underwent a PPT using barriers long, no direct contact. In the short SPT, behavior did not differ between species.
In the longer test, pronounced partner preferences emerged in prairie voles, but mice exhibited no social preferences and rarely huddled. No sex differences were evident in either test. Direct physical contact was required for partner preferences in huddling time in voles, but preference for the partner chamber was evident with or without contact.
Both prairie voles and mice are social, but they exhibit important differences in the specificity and extent of their social behavior. While mice are often used to study social approach and other behaviors, voles are a more suitable species for the study of selective social.
Full Text Available Social behavior is often described as a unified concept, but highly social group-living species exhibit distinct social structures and may make different social decisions. While mice are often used to study social approach and other behaviors, voles are a more suitable species for the study of. Tissue inhibitor of metalloproteinase-3 knockout mice exhibit enhanced energy expenditure through thermogenesis. Full Text Available Tissue inhibitors of metalloproteinases TIMPs regulate matrix metalloproteinase activity and maintain extracellular matrix homeostasis.
Although TIMP-3 has multiple functions e. TIMP-3 KO mice had higher body temperature, oxygen consumption, and carbon dioxide production than wild-type WT micealthough there were no differences in food intake and locomotor activity. In the treadmill test, oxygen consumption and carbon dioxide production were higher in TIMP-3 KO mice both before and after starting exercise, and the difference was more pronounced after starting exercise.
Our findings suggest that TIMP-3 KO mice exhibit enhanced metabolism, as reflected by a higher body temperature than WT micepossibly due to increased mitochondrial activity. Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye. Full Text Available Tear secretion is important as it supplies water to the ocular surface and keeps eyes moist.
Both the parasympathetic and sympathetic pathways contribute to tear secretion. Selenoprotein-deficient transgenic mice exhibit enhanced exercise-induced muscle growth. Dietary intake of selenium has been implicated in a wide range of health issues, including aging, heart disease and cancer. Selenium deficiency, which can reduce selenoprotein levels, has been associated with several striated muscle pathologies.
To investigate the role of selenoproteins in skeletal muscle biology, we used a transgenic mouse referred to as i6A- that has reduced levels of selenoproteins due to the introduction and expression of a dominantly acting mutant form of selenocysteine transfer RNA tRNA[Ser]Sec. As a consequence, each organ contains reduced levels of most selenoproteins, yet these mice are normal with regard to fertility, overall health, behavior and blood chemistries.
Like muscle in wild-type micethe enhanced growth in the i6A- mice was completely blocked by inhibition of the mammalian target of rapamycin mTOR pathway.
Muscles of transgenic mice exhibited increased site-specific phosphorylation on both Akt and p70 ribosomal S6 kinase p70S6k P accounting for the enhanced response to synergist ablation. Thus, a single genetic alteration resulted in enhanced skeletal muscle adaptation after exercise, and this is likely through subtle changes in the resting phosphorylation state of growth-related kinases. Mice with a targeted deletion of the tetranectin gene exhibit a spinal deformity. To test the functional role of tetranectin directly, we have generated mice with a targeted disruption of the gene.
We report that the tetranectin-deficient mice exhibit kyphosis, a type of spinal deformity characterized by an increased curvature of the thoracic spine. The kyphotic angles were Histological analysis of the spines of these mice revealed an apparently asymmetric development of the growth plate and of the intervertebral disks of the vertebrae. In the most advanced cases, the growth plates appeared disorganized and irregular, with the disk material Seiring dengan berkembangnnya sistem transportasi yang ada di dunia baik transportasi laut, darat, dan udara dimana dapat memudahkan seseorang atau sebuah kelompok berpergian dari satu wilayah ke wilayah lain, dari sinilah MICE meeting, incentive, convention, exhibition dilihat sebagai peluang bisnis dimana seseorang atau kelompok melakukan sebuah pertemuan atau konferensi conference.
Indonesia sudah berkembang menjadi salah satu negara tujuan bisnis dan wisata. Hal itu dibuktikan dengan p Trpc2-deficient lactating mice exhibit altered brain and behavioral responses to bedding stimuli. The trpc2 gene encodes an ion channel involved in pheromonal detection and is found in the vomeronasal organ. Consistent with previous studies, KO dams exhibited decreased maternal aggression and nest building, but we also identified deficits in nighttime nursing and increases in pup weight.
When exposed to the bedding tests, WT dams typically ignored clean bedding, but buried male-soiled bedding from unfamiliar males.
In contrast, KO dams buried both clean and soiled bedding. Differences in brain Fos expression were found between WT and KO mice in response to either no bedding, clean bedding, or soiled bedding. In the accessory olfactory bulb, a site of pheromonal signal processing, KO mice showed suppressed Fos activation in the anterior mitral layer relative to WT mice in response to clean and soiled bedding.
However, in the medial and basolateral amygdala, KO mice showed a robust Fos response to bedding, suggesting that regions of the amygdala canonically associated with pheromonal sensing can be active in the brains of KO micedespite compromised signaling from the vomeronasal organ.
Together, these results provide further insights into the complex ways by which pheromonal signaling regulates the brain and behavior of the maternal female.
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Male aromatase-knockout mice exhibit normal levels of activity, anxiety and “depressive-like” symptomatology. It is well known that estradiol derived from neural aromatization of testosterone plays a crucial role in the development of the male arbocongenant and the display of sexual behaviors in adulthood.
It was recently found that male aromatase knockout mice ArKO deficient in estradiol due to a mutation in the aromatase gene have arbiconvenant deficits in coital behavior and are sexually less motivated.
We wondered whether these behavioral deficits of ArKO males could be related to changes in activity, exploration, anxiety and “depressive-like” symptomatology.